Release date 1999
Implementation C++
Authors Liakopoulos, T., Pasquier, C., and Hamodrakas, S.

OrienTM (Liakopoulos et al. 1999, 2001) is a computer software that utilizes an initial definition of transmembrane segments to predict the topology of transmembrane proteins from their sequence. It uses position-specific statistical information for amino acid residues which belong to putative non-transmembrane segments derived from statistical analysis of non-transmembrane regions of membrane proteins stored in the SwissProt database. Its accuracy compares well with that of other popular existing methods.

Liakopoulos, T., Pasquier, C., and Hamodrakas, S. (1999), “OrienTM: A novel method to predict transmembrane protein topology,” in 21st conference of the hellenic society for biological sciences, Galissas, Syros island.

Liakopoulos, T., Pasquier, C., and Hamodrakas, S. (2001), “A novel tool for the prediction of transmembrane protein topology based on a statistical analysis of the SwissProt database: the OrienTM algorithm,” Protein Engineering Design and Selection, (Oxford, ed.), Oxford Academic, 14, 387–390. https://doi.org/10.1093/protein/14.6.387.

Claude Pasquier
Researcher in Computer Science / Computational Biology

Université côte d'Azur, CNRS, I3S Laboratory, Sophia Antipolis